Circles Around The Sun To Play Third-Ever Live Show, With Railroad Earth

first_imgChris Robinson Brotherhood guitarist Neal Casal‘s Circles Around The Sun project had added another date to their schedule. The group has announced it will play Railroad Earth‘s Horn o’ Plenty Getaway at the Sherman Theater in Stroudsburg, PA Thanksgiving weekend (Nov. 25th and 26th).As you may or may not know, Casal, joined by fellow CRB brethren keyboardist Adam MacDougall, drummer Mark Levy and bassist Dan Horne, created the setbreak music for the Grateful Dead‘s Fare Thee Well shows at Chicago’s Soldier Field last summer. With plenty of positive feedback after the Dead shows, it prompted the group to release Interludes For The Dead in proper album format.After playing their first official live performance at Lockn’ recently, the group announced a show at Brooklyn Bowl on Nov. 23rd.Tickets for RRE’s Plenty O’ Horn Getaway can be purchased here. [via Jambase]last_img read more

‘We want Wilder’: Team Joshua eager to fix unification fight

first_imgJapeth Aguilar embraces role, gets rewarded with Finals MVP plum Lights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew Asia League chief determined to get more PBA teams to join its tournaments British boxer Anthony Joshua enters the arena for his fight against Russian boxer Alexander Povetkin in their WBA, IBF, WBO and IBO heavyweight titles fight at Wembley Stadium in London, Saturday, Sept. 22, 2018. (AP Photo/Matt Dunham)LONDON — No sooner had Anthony Joshua brutally dispatched another pretender to his heavyweight titles than attention turned to who the British fighter would face next as he seeks to clean up boxing’s most glamorous division.An eagerly anticipated fight on Dec. 1 will go a long way to clearing that up.ADVERTISEMENT Allen Durham still determined to help Meralco win 1st PBA title Phivolcs: Slim probability of Taal Volcano caldera eruption Gov’t to employ 6,000 displaced by Taal Lights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew For Hearn, Wilder vs. Joshua — pitting the two biggest punchers in boxing together — would be one of the biggest fights in boxing history and would be must-see viewing, stylistically. There’s also the issue of unifying the belts while the opportunity is there.“We want to be undisputed heavyweight champion of the world,” Hearn said, looking across to Joshua.Hearn also sees Fury, a loudmouth out of the ring and a pragmatic boxer in it, as something of a turn-off.“I don’t want to be disrespectful here, but Tyson Fury is the most unentertaining fighter I’ve ever seen,” Hearn said, dismissively. “He’s never been in a good fight in his whole career. Deontay Wilder against Joshua is the biggest fight in world boxing and it’s the most exciting matchup you can make.”The Wilder and Joshua camps negotiated last year for a fight — there was talk of $50 million on the table — but couldn’t find a middle ground. Hearn is eager to resume talks and agree to a deal in the coming weeks that can be rubber-stamped as soon as Wilder beats Fury. He said $50m would be “peanuts” compared to what could be offer next year.ADVERTISEMENT Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award Deontay Wilder, the WBC champion, is scheduled to take on Tyson Fury, the former champion before drug and health issues got in the way, somewhere in Las Vegas. It’s a fight between two unbeaten heavyweights who represent the biggest threat to Joshua, the WBA, IBF and WBO belt-holder, and could provide his next opponent.Joshua, now with a 22-0 record after toughing out a victory over Alexander Povetkin in front of 80,000 at Wembley Stadium on Saturday, said he isn’t bothered who wins out of Wilder and Fury. In fact, he even suggested he won’t even watch it.FEATURED STORIESSPORTSGinebra beats Meralco again to capture PBA Governors’ Cup titleSPORTSJapeth Aguilar wins 1st PBA Finals MVP award for GinebraSPORTSGolden State Warriors sign Lee to multiyear contract, bring back ChrissHis promoter has other ideas, however.“We want Wilder,” Eddie Hearn said.center_img Sports Related Videospowered by AdSparcRead Next MOST READ “I don’t want to wait until December for him to finish his fight, get some rest and then start negotiating,” said Joshua, who is contractually obliged to return to Wembley on April 13 for his next fight. “I start training for a fight again early January. I want to get my fight fixed as soon as possible this side of the year, so I know what I’m doing next year.”Aside from what will undoubtedly by tough negotiations with Wilder’s people, another possible barrier for Hearn will be if Fury wins on Dec. 1. That would make a rematch likely, and also make Wilder a less-appealing prospect.Joshua would then have to turn to someone like fellow Briton Dillian Whyte for his April 13 fight.So, it’s a case of wait and see for Joshua, who has a seven-month break before getting back in the ring. He’ll do so with more experience in the bank after a difficult fight against Povetkin that started with the Briton getting a busted nose in the first round and ended with a devastating flurry of punches that sent the 39-year-old Russian nearly stumbling through the ropes.In his last two fights, Joshua has beaten the previously undefeated Joseph Parker convincingly on points and then inflicted only Povetkin’s second career loss. They were both ranked as the No. 3 heavyweight in the world when they took on Joshua, who realistically only has two credible rivals currently in the division.Fury has returned after a 2 1/2-year absence with two almost farcically easy fights, which gave him some much-needed time in the ring but barely proved a thing.Fury vs. Joshua — the bad boy against the poster boy — would get Britons excited but Wilder vs. Joshua really gets the pulses racing.“No problem, I fight whoever,” Joshua said. “I’ll always knock them down, one by one.” Nadine Lustre’s phone stolen in Brazil Don’t miss out on the latest news and information. View comments Gretchen Barretto’s daughter Dominique graduates magna cum laude from California college Tim Cone, Ginebra set their sights on elusive All-Filipino crown LATEST STORIESlast_img read more

Researchers develop 3D model of human placenta

first_imgAug 3 2018The placenta is the organ connecting mother and embryo. Its main functions are the exchange of nutrients, gases and metabolic products and the production of hormones and other substances essential for embryonic development. Placental malfunctions are the main cause of pregnancy complications and can lead to miscarriage and other serious disorders that endanger both mother and child. So far, the mechanisms underlying these disorders remain largely unexplained, not least because, up until now, there has been no reliable human cell culture model system. MedUni Vienna researchers have now successfully developed a 3D model of the human placenta. The 3D “in vitro” model of the early human placenta was produced in a collaborative project involving the research groups of Martin Knöfler from MedUni Vienna’s Department of Obstetrics and Gynecology (Division of Obstetrics and Gynaecology) and Paulina Latos from MedUni Vienna’s Center for Anatomy and Cell Biology.First organoid model of the placenta – based on other tissue culture models”Over the last few years, 3D tissue culture models, called organoids, have rapidly been established for many different human organs. In most cases, these organoids consist of only a few cell types from the respective tissue and therefore have a simpler structure than the original organ,” explain the researchers. Working on this basis, the team from the Medical University of Vienna managed to develop an organoid model of the placenta, consisting of the prevailing placental cell population, so-called trophoblasts.Knöfler and Latos explain: “As a puretrophoblast organoid without blood vessels or connective tissue components, this model mirrors the trophoblast-specific placental structure in a Petri dish.” This was done by optimising the culture conditions that had already been successfully applied in organoid models of other tissues.Related StoriesAMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapySlug serves as ‘command central’ for determining breast stem cell healthNew study reveals ‘clutch’ proteins responsible for putting T cell activation ‘into gear’A significant advantage of the placenta organoids is their capacity for self-organisation, self-renewal and constant growth, stress the MedUni Vienna scientists, since they contain both stem cells and progenitors. Moreover, these 3D structures also contain the three main cell types of the human trophoblast population.The MedUni Vienna researchers were able to underpin the groundbreaking advantages of this organoid system with a study substantiating the role of the WNT signaling pathway (which is crucial for development and growth of many tissues) in self-renewal and differentiation of the trophoblast organoids. The organoid model system can also be pharmacologically and genetically manipulated. This opens up new possibilities for studying physiological and pathophysiological processes of the human placenta.”The fact that there were no self-renewing cell culture model systems available for the human placenta made it difficult, if not impossible, to study the causes of malfunctions. Establishment of the placenta organoid system will improve this situation significantly and will help advancing drug development and consequently medical treatments for dangerous gestational disorders,” emphasises Knöfler, one of the leading international experts in placental research and last author of the study.Source: https://www.meduniwien.ac.at/web/en/about-us/news/detailsite/2018/news-im-august-2018/3d-model-of-human-placenta-developed/last_img read more